西班牙专利ES2631191A1 Composition for solar protection and repair of the skin through complex protectors (Machine-translat

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专利摘要:
A composition or combination for sun protection and/or skin repair by exposure to solar radiation characterized by comprising components that act as photodimeric filters (allantoin, panthenol, tocopherol acetate, tocopherol, sodium ascorbyl phosphate, aloe barbadensis), in defined percentages. In a preferred case, the combination may also contain at least one photoprotective compound against solar radiation, which is preferably an ultraviolet filter. Another object of the invention is a product, preferably cosmetic and more preferably still for topical use for skin care, comprising the above composition as one of its ingredients, as well as the use of both for the care of the skin by protection and repair before solar radiation. (Machine-translation by Google Translate, not legally binding)
公开号:ES2631191A1
申请号:ES201630108
申请日:2016-01-29
公开日:2017-08-29
发明作者:Manuel Jose ALONSO GRACIA；Ana POLO SOLER；Angel BALAGUER TIMOR；Ana GONZALVEZ ILLUECA；Lidia Maria CHORNET ORERO；Mercedes ALGARRA CARBONELL；Maria Del Pilar MONTORO MARTINEZ
申请人:Rnb S L；Rnb SL；
IPC主号:

专利说明:

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COMPOSITION FOR SOLAR PROTECTION AND REPAIR OF SKIN THROUGH PROTECTIVE COMPLEXES
DESCRIPTION
Technical field
The present invention is included in the field of Chemistry, specifically Cosmetics, its object being related to the development of compositions for the protection of the skin by means of photoprotective complexes against the damages caused by solar radiation (ultraviolet A -UVA- , ultraviolet B -UVB-, infrared -IR- and visible) and in particular against the damage caused by reactive oxygen species (ROS) of the English “Reactive Oxygen Species”) caused mainly by said radiation.
Background of the invention
The action of the sun on human skin has multiple effects, both positive and negative, that show great variability mainly based on two factors: the phototype of the individual (ability of the skin to assimilate solar radiation) and the exposure time to solar radiation.
From a beneficial point of view, sun exposure stimulates melanin production causing skin tanning, which may be desirable from an aesthetic point of view. In addition, the action of the sun is essential for the synthesis in the skin of vitamin D, whose function in the body is to maintain normal levels of calcium and phosphorus in plasma. Vitamin D deficiencies can cause several diseases, such as rickets.
On the contrary, excessive exposure to the sun is no longer beneficial to produce adverse health effects. Thus, prolonged exposure is a short-term cause of minor aggressions such as burns, redness and inflammation (erythema) and in the long term is responsible for more serious diseases such as acceleration of skin aging (appearance of wrinkles, loss of volume and density that they cause changes in appearance and functions in the skin, such as increased sensitivity to UV radiation and a reduction in immune function) and various types of skin cancer.
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Many of the mechanisms by which the sun produces these adverse effects are known and are mainly due to the interaction of solar radiation with the different cellular components, which varies depending on the band of the electromagnetic solar spectrum. Thus, UVB radiation, which has a wavelength between 290 and 320 nm, mainly attacks the epidermis and is primarily responsible for sunburn and most of the different types of skin cancer (such as spinocellular carcinoma ), by directly damaging the DNA of the cells and inducing mutations. For its part, it is believed that UVA radiation, which is characterized by a wavelength between 320 and 400 nm., Is closely related to the melanoma genesis and is primarily responsible for oxidative stress due to formation and release in the organism of free radicals or reactive oxygen species (ROS), responsible for molecular changes that are associated with cutaneous photo-aging. Over time, skin damage occurs that accelerates their aging due to the accumulation of these free radicals, since they are atoms or molecules that contain a single electron missing in an outer layer and therefore have a great capacity to injure all cell structures, including lipids and proteins. Although under normal circumstances the antioxidants of the skin manage to trap and neutralize these ROS, this capacity is drastically reduced by excessive exposure to UVA rays, which accelerate oxidative stress and cause injury to all the components of the skin cell.
One of the effects of reactive oxygen species generated by solar radiation is lipid peroxidation, which affects the lipids of cell membranes, interfering with membrane-associated cell signaling events. Another harmful effect is damage to the DNA of the cutaneous cells, by forming 8-hydroxy-2’-deoxyguanosine that if not repaired by the natural mechanisms of protection of the cells, can cause mutations by GC to TA transversion. Reactive oxygen species can also induce the synthesis of metalloproteinases, cause modifications in the structure of proteins and increase elastin deposits in the dermis. All these biological processes are related to skin aging.
The skin has natural defenses (endogenous photoprotection) of various types against these environmental aggressions caused by sun exposure. Melanin for example, pigment whose production is stimulated by solar radiation, is a good
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filter against radiation of 305 and 365 nm. Another defense mechanism is constituted by antioxidant molecules naturally present in the cells, which can be proteins with antioxidant enzymatic functions or non-protein molecules of low molecular weight. Low molecular weight non-enzymatic antioxidants include vitamin E, fat soluble in cell membranes.
In addition to having natural defenses against sun protection, individuals whose activity will suffer prolonged exposure to the sun can apply effective exogenous protection strategies. One of these strategies is to avoid the sun, if possible, in the central hours of the day, and wear hats, sunglasses and appropriate clothing that protect the skin. Another widely used and known strategy, which encompasses the present invention, is the use of topical photoprotective compositions in the form of creams, lotions, or similar formulations. These compositions comprise substances capable of absorbing, reflecting or dispersing solar radiation, reducing their adverse effects.
Molecules such as vitamins, panthenol, alantolna and aloe and licorice extracts are included within the group of topical photoprotective substances or complexes. It has been shown that exposure to solar radiation reduces the natural levels of endogenous antioxidant substances, which, as said, prevent skin aging naturally, so the use of antioxidant substances is recommended as oral systemic supplements or as topical compositions before intense and / or prolonged exposure to the sun (Rossi T., et al., in vivo, 2005, 19: pp. 319-322).
Antioxidants are very reactive molecules and therefore unstable. In addition, to be effective as photoprotective agents they must be used in adequate concentrations. A problem of the formulations that use antioxidant substances is to find the appropriate formulation at appropriate concentrations that ensure the stability of the molecule while at the same time maintaining a therapeutic effect when used for sun protection (Gilaberte Y., et al., Minutes Dermosifiliograficas, 2003, Vol. 94 (5): pp. 271-93).
As for vitamins, they are natural antioxidant substances and can be used in compositions and preparations to prevent the negative effects of
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ROS (Manela-Azulay M., et al., Clinics in Dermatology, 2009, 27: pp. 469-474). Vitamin E in particular is naturally present in the skin. It is an effective antioxidant compound suitable to combat the harmful effects of sun exposure. Compositions comprising vitamin E (mainly in the form of tocopherol or tocopherol acetate in concentrations ranging from 1% to 5%) are used in topical preparations for these properties. Vitamin E helps reduce erythema when used before sun exposure, but does not seem to have the same effect if used after exposure. Vitamin C for its part is one of the main natural antioxidants present in human skin. Its topical use is supported by its effectiveness in naturally protecting intracellular structures against oxidative stress. Vitamin C in its active form, L-ascorbic acid, is very unstable due to its oxidation by the action of air; to improve its stability, esterified derivatives are used, such as ascorbyl phosphate.
Another antioxidant compound useful as a protector against the effects of solar radiation is dexpanthenol, stereoisomer D of panthenol, a precursor to pantothenic acid (vitamin B5). This compound is frequently used in cosmetic preparations thanks to its moisturizing properties. It is a stable compound and has been demonstrated in erythema models caused by ultraviolet radiation that has an anti-inflammatory effect (Ebner F., et al., Am. J. Clin. Dermatol., 2002; 3 (6): pp 427433).
Alantolna, a product of the degradation of purines in most mammals, excluding primates, has antioxidant activity against reactive oxygen species. Its action is known as a general action systemic antioxidant (Guskov E.P., et al., Doklady Biochemistry and Biophysics, 2001, Vol. 379: pp. 239-242). Due to its moisturizing properties, it is often used in cosmetic and personal hygiene products, including sunscreen creams. It is also used in pharmaceutical products and is considered a safe and non-toxic compound.
The use of Aloe extracts as antioxidant agents that have been very effective is also known. Studies in a sunburn model produced by UVB in rats have shown that extracts of Aloe saponaria are effective in reducing pain and inflammation thanks to its antioxidant properties (Silva
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M.A., eta al., Journal of Photochemistry and Photobiology B: Biology 133, 2014: pp. 47-54); Similar anti-inflammatory and antioxidant effects are already known for other Aloe species, such as Aloe Vera.
Finally, it has been shown that licorice extracts can be used to reduce damage caused by solar radiation due to their antioxidant properties and their use in topical formulations for the prevention of skin cancer has been suggested (Rossi T., et al ., in vivo, 2005, 19: pp. 319-322). This study demonstrates that one of the active compounds of licorice extracts, glycyrrhizin, increases the expression of Bcl-2 in the SKMEL-28 melanoma cell line after UVB irradiation, although the molecular mechanism involved is not still fully known.
For all these beneficial properties, these antioxidant compounds are increasingly used in the food, cosmetics, cosmoceutics and pharmaceutical industries, in particular in applications related to the protection of acute damage caused by exposure to the sun, or related to prevention. and / or treatment of skin photoaging.
Thus, patent application GB2478967 (A) discloses a product specifically designed for hair care (but not skin care) comprising green tea extract, karite butter extract, vitamin E acetate (tocopherol acetate) and Vitamin A palmitate. Preferred formulations of this product may optionally include components such as alantolna, panthenol and / or a UV filter (for example benzophenone-4).
For its part, patent application KR20120001597 (A) discloses a cosmetic composition for the prevention of long-term skin aging (although not for immediate sun protection) based on a unique biologically active ingredient: panthenol, as well as other ingredients additional with the ability to block UV radiation. Synergies between them are not analyzed, and therefore the composition is limited sun protection. The invention is based on the daily contribution of the composition whose effect is obtained in the long term and not immediately (contrary to the present invention).
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Also patent application KR20140143940 (A) discloses an extract of Aloe vera for the prevention and treatment of skin aging, in particular the photoaging of the skin caused by exposure to UV radiation. The document also teaches a cosmetic composition and a pharmaceutical composition to prevent and treat skin aging, which contain said Aloe Vera extract. As in the previous application, the composition focuses on a single active ingredient, without synergies, and is not aimed at immediate sun protection.
Japanese patent application JPH06172150 (A) discloses a cosmetic product for the care of skin blemishes (not immediate sun protection), including freckles and sunburn, returning to the skin its natural coloration. The cosmetic product comprises at least one compound selected from between the glycyrrhrenic acid and its esters and at least one compound selected from between ascorbyl phosphate and its salts, that is, they are essentially composed of two biologically active agents.
As for the international application WO2013003803 (A1), it is aimed at the development of new vehicles of active agents in topical formulas, for deposition on the surface of the skin, such as tocopherol microcapsules and other components, such as protective agents solar.
Patent application US2015118334 (A1) is focused on the treatment and prevention of chronic cutaneous inflammatory diseases or allergic skin reactions through natural extracts with active ingredients that are mostly considered highly degradable for topical use compositions, such as dipotassium glycyrrhinate, acid hyaluronic, rhubarb ralz extract, Cnidium fruit extract, skullcap ralz extract and a dermatologically acceptable vehicle.
These known compositions of the state of the art, although they show exogenous defense effects to solar radiation thanks to the active agents they comprise and the vehicles used for their deposition, are not focused on the problem of immediate photoprotection and during sun exposure , which reduces its effectiveness and usefulness. In addition, these compositions tend to focus on one or two active sunscreen agents, which, as has been seen, have a specific range of action on spectrum radiation and their particular effects on the
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organism, and do not analyze the possible synergies between components of this type that can offer a broader and more comprehensive protection against radiation. This synergistic effect is not evident or immediate since it does not derive from the sum of the effects of the compounds, in fact a problem related to the preparation of these topical compositions is their instability or indeterminacy when it comes to knowing how they will interact with the skin and with the rest of the elements of the composition, which makes its use very uncertain from the point of view of health.
In order to solve these problems of the prior art, the present invention is thus directed to a composition based on the inclusion of several active principles of protection against solar radiation, antioxidant vitamins, anti-inflammatories, moisturizers and skin repair, each of them with its own operating mechanism, whose synergy accentuates its protective effect, and which together show also a very unusual stability for compositions of this type.
Description of the invention
The subject of the present invention is a composition for the protection and solar repair of the skin that is characterized in that it comprises:
a) alantolna, in a concentration between 0.1 and 1%;
b) panthenol, in a concentration between 0.1 and 5%;
c) tocopherol acetate, in a concentration between 0.05 and 2%;
d) tocopherol, in a concentration between 0.01 and 1%;
e) sodium ascorbyl phosphate, in a concentration between 0.01 and 3%; Y
f) Aloe barbadensis, in a concentration between 0.001% and 5%.
The indicated percentages refer to percentages by weight with respect to the total weight of the composition, and the limits of the intervals are included in the scope of the invention.
The protective and reparative composition of the skin against the effects of the sun can be a composition in itself as described, that is to say a product, or as will be seen later it can be understood as a combination of the constituent components, that combined have the intended effects of protection and repair of the skin.
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The composition described here in its essential form achieves a significant increase in the protection of the skin against the effects of the sun thanks to the combined use of the ingredients. The benefits are due to the synergy that is achieved by using assets that act at different levels:
- The antioxidants tocopherol acetate, tocopherol, sodium ascorbyl phosphate and Aloe barbadensis act by reducing free radicals (ROS) generated by radiation.
- The active ingredients panthenol and alantolna act as anti-inflammatories, avoiding the additional production of ROS associated with inflammatory processes (these could be triggered due to radicals that have not been eliminated by the antioxidants indicated above).
In this way, the real damage of solar radiation is minimized since it acts at different biological levels.
The six components listed as essential in the formulation object of protection, which are referred to herein as "photodermic protectors" or "photodermic filters" to simplify, have an antioxidant and anti-inflammatory function that neutralizes the effects of ROS on the skin, acting as photodermic filters.
Apart from the active sunscreen agents listed until now called photodermic protectors, the composition may optionally contain one or more of the following elements: licorice extract (dipotassium glycyrrhizate), in a percentage of up to 0.2% by weight of the total composition; ubiquinone, in a percentage of up to 0.2%; and bisabolol, in a percentage of up to 0.2%; as well as up to 0.5% of the raw material containing other natural antioxidant compounds other than those mentioned above, preferably from the family of polyphenols and / or carotenoids such as hydroquinones, resveratrol, tannins, ferulic acid, astaxanthin and the like.
The present composition may additionally comprise in one preferred case one or more photoprotective compounds against solar radiation. These photoprotective compounds also act as filters against solar radiation, exerting a
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complementary function to other photodermic protectors and enhancing the protection and repair of the skin by sun exposure. The photoprotective compounds are preferably protective compounds against ultraviolet, UVA and / or UVB radiation. Each of these photoprotective compounds (which can also be referred to herein as UV filters) may be included in the composition in a concentration comprised in the legal limits, and this preferred concentration being between 0.1% and 30% by weight of the total composition , more preferably still between 0.1% and 28%, more preferably even 0.1% and 15% and in the most preferred case of all between 0.01% and 10%. The photoprotective compounds against ultraviolet radiation may be selected from those designated in Annex VI ("Lists of ultraviolet filters admitted to cosmetic products") of Regulation (EC) n. 1223/2009 of the European Parliament and of the Council of November 30, 2009 on cosmetic products. The components of this list are listed below, with the percentage by weight of maximum composition that cannot be exceeded by including this filter in the formulation, in accordance with the law:
- Bis-ethylhexyloxyphenol methoxyphenyl triazine: maximum 10%
- Butyl methoxy dibenzoylmethane: maximum 5%
- Diethylamino hydroxybenzoyl Hexyl Benzoate: Maximum 10%
- Phenyl dibenzimidazole tetrasulfonate disodium: Maximum 10%
- Drometrizol T risiloxane: Maximum 15%
- Methylene bis-benzotriazolyl tetramethylbutylphenol (nano): Maximum 10%
- Terephthalidene-sulphonic dialcamphoric acid: Maximum 10%
- 4-Methylbenzylidene Camphor: Maximum 4%
- 3-benzophenone: Maximum 10%
- 4- benzophenone: Maximum 5%
- Diethylhexyl butamide triazone: Maximum 10%
- Ethylhexyl methoxycinnamate: Maximum 10%
- Ethylhexyl salicylate: Maximum 5%
- Ethylhexyl Triazone: Maximum 5%
- Ethylhexyl dimethyl PABA: Maximum 10%
- Homomentil salicylate (homosalate): Maximum of 10%
- Isoamil p-methoxycinnamate: Maximum 10%
- Octocrylene: Maximum 10%
- Phenylbenzimidazole sulfonic acid: Maximum 8%
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- Polysilicone 15: Maximum 10%
- Titanium dioxide: Maximum 25%
- Bis-triphenyl triazine (nano): Maximum of 10% and any combination thereof.
More preferably, the photoprotective compounds are selected from the group consisting of those described in the examples herein, which are categorized as UV filters and are listed below with their maximum percentage of addition followed by the preferred percentage range with which It is included in the final composition:
- Butyl methoxy dibenzoylmethane: maximum 5%, preferably between 0.25% and 4.5%;
- Phenyl dibenzimidazole tetrasulfonate disodium: Maximum 10%, preferably between 0.5% and 3%;
- Diethylhexyl butamide triazone: Maximum of 10%, preferably between 0.5% and 3%;
- Ethylhexyl salicylate: Maximum of 5%, preferably between 1.5% and 4.8%;
- Ethylhexyl triazone: Maximum of 5%, preferably between 2.5% and 4.5%
- Octocrylene: Maximum of 10%, preferably between 0.50% and 10%;
- Phenylbenzimidazole sulfonic acid: Maximum 8%, preferably between 1 and 3%;
and any combination thereof. UV filters may be incorporated into the formulation in any of the values within the preferred percentage ranges, the examples being illustrative only and not limiting.
In a particular embodiment of the invention, the composition for the protection and solar repair of the skin forms part (is a component) of a cosmetic product, whereby another object of the present invention is a cosmetic product which comprises in its formulation the composition for the protection and solar repair of the skin described above, in any of its variants. The composition object of the invention can also be, in another particular embodiment, a cosmetic composition in itself. In either case, the cosmetic composition or cosmetic product may be presented in the form of a formulation suitable for use.
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topical, such as a cream, an emulsion, a lotion, an ointment, an aerosol, or a similar formulation, which is preferably designed for the care (protection and repair) of the skin. When the present invention relates to a cosmetic composition (which is preferably for topical use), in any of its previous variants and either the composition itself or the cosmetic product that comprises it, it is understood that it also includes conventional excipients commonly used for this type of products, and that can be presented in any of the forms listed in this paragraph. The excipients can be of the type: gelling and emulsifying agents, surfactants, consistency factors, preservatives, emollients and humectants, rheological modifiers, pH adjusters, chelants, silicones, waxes, fragrances and perfumes, skin conditioners, etc. which are commonly used in cream, emulsion, lotion, gel, ointment, aerosol or similar formulations, and appear in sufficient quantities until the total composition is completed. It is evident that in a particular and preferred case the product comprises, in addition to the composition for the protection and solar repair of the skin, one or more photoprotective compounds against solar radiation, which are preferably filters against ultraviolet radiation, UVA and / or UVB.
The cosmetic product can be prepared in a conventional manner by methods and techniques known in the field, for example by preparing an emulsion of aqueous phase components and fatty phase components, which are added and mixed by continuous stirring (for example, in a manner preferably at 1000015000 rpm for 2-15 minutes, more preferably at 12000 rpm for 5-10 minutes) at a temperature between 70 ° C-95 ° C, preferably between 80 ° C-85 ° C. Subsequently, the emulsion is cooled, even under continuous stirring to a temperature between 35 ° C-45 ° C and preferably 40 ° C, to then add the thermolabile components of the product (active ingredients, preservatives and perfume), stirring the total mixture at a speed between 10000-15000 rpm for 2-5 minutes, more preferably at 12000 rpm for 3 minutes, to ensure complete homogenization of the assembly.
Particularly, based on the above indications, the product of the present invention is prepared by one of the following two alternatives to obtain the same result: a) or the composition for the protection and solar repair of the skin is added only once. in one of its stages, as a single component such
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which has been described here, b) or the components of said composition are added separately, in different stages and according to their properties, with the rest of the ingredients of the formulation (or in the preparation of the aqueous and fatty two-phase emulsion or as thermolabile components). In this case, the composition for the sun's protection and reparation of the skin should be understood as a combination of the elements described above as part of its composition, whether essential or optional. Thus, mixing the elements defined in general as photodermal protectors (together or separately with the photoprotective compounds or UV filters when added) will have the same effects of protection and repair of the skin during and after exposure to the sun whether they are added to the cosmetic product as a single composition or separately during its preparation.
In either case, the result object of the present invention is a cosmetic product, preferably of topical use, which comprises in its formulation at least:
a) alantolna, in a concentration between 0.1 and 1%;
b) panthenol, in a concentration between 0.1 and 5%;
c) tocopherol acetate, in a concentration between 0.05 and 2%;
d) tocopherol, in a concentration between 0.01 and 1%;
e) sodium ascorbyl phosphate, in a concentration between 0.01 and 3%; Y
f) Aloe barbadensis, in a concentration between 0.001% -5%, referring the indicated percentages to percentages by weight with respect to the total weight of the product, and being the limits of the intervals included in the scope of the invention. All the variants and alternatives discussed above for these components (for example, comprising or not comprising photoprotective compounds that are UV filters) are also applied here for the case of the cosmetic product.
Also in any of the cases described, a formulation of the preferred cosmetic product 100% complete by weight comprises so-called photodermic protectors up to 10% by weight, more preferably even up to 5% and more preferably even up to 4% (all in set), with a sufficient amount of excipients. When it also comprises at least one photoprotective compound, it appears in a percentage by weight of the total comprised between 0.1% and 30%, including both limits.
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The following describes the preferred composition of 100% by weight thereof that any of the cosmetic products prepared according to the present invention may present, regardless of the type (body sun milk, facial sun cream, body sun spray, among others, as the examples:
Ingredients % by weight of the total product
Photodermic Filters 1% - 4%
Flavoring (perfume) 0.2% - 0.7%
Preservatives 0.5% - 2%
Other ingredients 16% - 25%
Water Until completing 100%, being able to be between 40% -75%
In a more preferred case, in which the composition (and the product) further comprises photoprotective compounds that are UV filters, the product formulation is:
Ingredients % by weight of the total product
Photodermic Filters 1% - 4%
UV filters 0.5% - 28%
Flavoring (perfume) 0.2% - 0.7%
Preservatives 0.5% - 2%
Other ingredients 16% - 25%
Water Until completing 100%, being able to be between 40% -75%
According to the present specification, as "other ingredients" apart from water, perfume and preservatives include emollients, pH regulators, emulsifiers, active ingredients, chelants and solubilizers, among the most important.
The composition (or combination) object of protection in any of its variants, as well as the cosmetic product that comprises it, preferably has a sun protection factor (SPF) between 6 and 60.
Also object of the present invention is a cosmetic use of the topical composition described above (and by extension, of the cosmetic product of topical use), which is characterized in that it is effective as an agent for the sun protection of the
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skin. Preferably, the topical composition or topical product is used for sun protection of facial or body skin. Another associated cosmetic use of the composition and the product that comprises it is as an agent for skin repair (preferably facial or body). By "skin repair" it should be understood that it has and exerts anti-aging, antioxidant and anti-inflammatory effects of the set of assets included, after the individual's sun exposure (for example in an aftersun or in a daily use cream).
Examples
Below are several examples that illustrate the invention, based on different formulas that meet the requirements set forth above for the essential composition and total formulation. These examples show the intended benefits for the combination of components, and refer to compositions with different qualitative and quantitative combinations of the components that act as photodermal protectors: the essential ones, which are alantolna, panthenol, tocopherol acetate, tocopherol and ascorbil sodium phosphate, in addition to Aloe barbadensis (whose most common form of use is leaf juice powder); ace! as the proposed options that can be added additionally: at least one of licorice extract (dipotassium glycyrrhizate), ubiquinone, bisabolol and raw material that contains other natural antioxidant compounds other than those mentioned above, preferably from the family of polyphenols and / or carotenoids such as hydroquinones, resveratrol, tannins, ferulic acid, astaxanthin and the like. These examples also illustrate cases in which the composition additionally comprises different concentrations of UV protective filters.
Method of preparation of the topical use compositions object of the present invention
In order to be able to compare all the results regarding the degree of protection against solar radiation and sensory properties, the manufacturing process of the samples of cosmetic products comprising the composition in the examples was unified as much as possible following. In general, the ingredients of the aqueous phase were weighed and mixed (among them, tocopherol acetate and part of the UV filters), heating to 80-85 ° C under continuous stirring. The rest of the components of the fatty phase (including the alantolna and the remaining part of the UV filters) continued to be added keeping the temperature between 80-85 ° C. It has been made
the emulsion with the two phases under the conditions of 80-85 ° C, 12000 rpm, for 510 minutes. Subsequently, the cooling process was started under continuous agitation. Once a temperature below 40 ° C was reached, the rest of the thermolabile ingredients (active and preservative and perfume, including panthenol, 5 Aloe barbadensis, sodium ascorbyl phosphate and panthenol) were added. Finally, the mixture was stirred at 12,000 rpm for 3 minutes to ensure complete homogenization of the whole.
Example 1: Formula solar body milk with theoretical SPF 15, with and without 10 photodermic filters
A formula according to the present invention, called Formula 1, was prepared in two variants: without part of the majority of essential components listed in claim 1 (referred to as simplifying "photodermic filters" or "photodermic protectors") and with them, to check the effects of its addition and the possible synergy with the rest of the components (photoprotective or UV filters, and excipients), with the specific composition presented in Table 1 in percentages by weight with respect to the total composition :
Table 1a - Composition of Formula 1, with and without photodermic filters
Adding Phase Ingredients 0 /% (without filters) 0 /% (with filters) Category / function
Grease Potassium Cetyl Phosphate (and) Hydrogenated Palm Glycerides 1,500,000 1,500000 Emulsifier
Grease Glyceryl Stearate 0.300000 0.300000 Emulsifier
Grease Cetearil alcohol 1,500000 1,500000 Rheological Additive
Grease Phenoxyethyl Caprylate 4,000000 4,000000 Emollient
Grease Ethylhexyl Isononanoate 3,000000 3,000000 Emollient
Grease Hydroxyacetophenone 0.500000 0.500000 Preservative
Grease Tocopherol acetate - 0.250000 F. Photodermic
Grease Butyl methoxy dibenzoylmethane 3,000000 3,000000 UV filter
Grease Octocrylene 5,250000 5,250000 UV filter
Grease Ethylhexyl salicylate 4,500000 4,500000 UV filter
Watery Water 66,733000 65,100,000
Watery Carbomero 0,100000 0,100000 Additive
Rheological
Watery Xantana Gum 0.200000 0.200000 Rheological Additive
Watery Glycerin 5,000000 5,000000 Emollient
Watery Allantoin - 0.500000 F. Photodermic
Watery Phenylbenzimidazole sulfonic acid 1,000000 1,000000 UV filter
Watery Sodium hydroxide 0.257000 0.279500 pH regulator
Thermolabiles Cyclopentasiloxane 2,000000 2,000000 Emollient
Thermolabiles 1,2-hexanediol and caprilyl glycol 0.300000 0.300000 Preservative
Thermolabiles Phenoxyethanol 0.200000 0.200000 Preservative
Thermolabiles Panthenol - 0.500000 F. Photodermic
Thermolabiles Aloe barbadensis (leaf juice powder) - 0.500000 F. Photodermic
Thermolabiles Ascorbil sodium phosphate 0.150000 F. Photodermic
Thermolabiles Dipotassium Glizarrate - 0.200000 F. Photodermic
Thermolabiles Tocopherol - 0.020000 F. Photodermic
Thermolabiles Tetrasodium glutamate diacetate 0.200000 0.200000 Chelator
Thermolabiles Pefume 0.400000 Perfume
TOTAL 100,000000 100,000000
The same property studies are applied to the two formulas presented in Example 1 in order to perform a comparative analysis. Studies are carried out both in silico, in vitro and in vivo following the legislation in force in the FPS study.
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Table 1b - Results of the studies performed In silico, In vitro and In vivo with the compositions of Formula 1 regarding the degree of sun protection, and properties
of sensory composition
Method Without photodermic filters With photodermic filters Reference
In silico 17.8 17.8 A simulation of the sun protection factor was performed in vivo (SPF, ISO24444). A description of the calculations made can be found in "In silico Determination of Topical Sun Protection", Bernd Herzog and Uli
Osterwalder, Cosmetic Science Technology 2011, 62-70
In vitro 18 15 ISO 24444
In vivo 19.2 53 ISO 24443
Viscosity (0.7 - 1.6) PaS (0.6 - 1) PaS Reometer
Sensory Milk of easy extension and rapid absorption. Light milk with easy extension and rapid absorption Visual inspection
The conclusions of the comparison made between the two variants of Formula 1 are as follows:
- The incorporation of the components called photodermic filters
5 increases the SPF In vivo 2.8 times compared to the formula without photodermic filters,
maintaining the concentration of UV filters and therefore their SPF values In vitro and In silico.
- The addition of photodermic filters improves the sensoriality of the final product.
10 Example 2: Formula facial sunscreen with theoretical SPF 30, with and without photodermic filters
A formula according to the present invention, called Formula 2, was prepared in two variants: without part of the majority of essential components listed in claim 1 (referred to as simplifying "photodermic filters") and with them, for
15 to test the effects of its addition and the possible synergy with the rest of the components (photoprotective or UV filters, and excipients), with the specific composition presented in Table 2 in percentages by weight with respect to the total composition :
20 Table 2a - Composition of Formula 2, with and without photodermic filters
Adding Phase Ingredients 0 /% (without filters) 0 /% (with filters) Category / function
Grease Potassium Cetyl Phosphate (and) Hydrogenated Palm Glycerides 2,200,000 2,200,000 Emulsifier
Grease Docosanol (behenyl alcohol) 1,500,000 1,500000 Rheological additive
Grease PEG-100 stearate and glyceryl stearate 1,200,000 1,200,000 Emulsifier
Grease Ethylhexyl Isononanoate 1,000000 1,000000 Emollient
Grease Triglyceride of caprylic / capric acid 2,000000 2,000000 Emollient
Grease Hydroxyacetophenone 0.500000 0.500000 Preservative
Grease Tocopherol acetate - 0.250000 F. Photodermic
Grease Butyl methoxy dibenzoylmethane 4,000000 4,000,000 UV filter
Grease Octocrylene 10.000000 10.000000 UV filter
Grease Ethylhexyl salicylate 4,500000 4,500000 UV filter
Grease Diethylhexyl butamide triazone 1.000000 1.000000 UV filter
Grease Silice 1.500000 1.500000 Emollient
Watery Water 53.780000 51.140000
Watery Xantana Gum 0.200000 0.200000 Rheological Additive
Watery Glycerin 4,000000 4,000000 Emollient
Watery Allantoin - 0.500000 F. Photodermic
Watery Phenylbenzimidazole sulfonic acid 2.000000 2.000000 UV filter
Watery Phenyl dibenzimidazole tetrasulfonate disodium 0.500000 0.500000 UV filter
Watery Sodium hydroxide 0.420000 0.420000 pH regulator
Thermolabiles Denat alcohol 6.000000 6.000000 Solubilizer
Thermolabiles Caprilil methicone 2.000000 2.000000 Emollient
Thermolabiles 1,2-hexanediol and caprilyl glycol 0.300000 0.300000 Preservative
Thermolabiles Phenoxyethanol 0.200000 0.200000 Preservative
Thermolabiles Panthenol - 0.500000 F. Photodermic
Thermolabiles Aloe barbadensis (leaf juice powder) - 0.020000 F. Photodermic
Thermolabiles Ascorbil sodium phosphate 0.150000 F. Photodermic
Thermolabiles Dipotassium Glizarrate - 0.200000 F. Photodermic
Thermolabiles Tocopherol - 0.020000 F. Photodermic
Thermolabiles Ammonium Acrylodimethyl Restaurant / VP Copolymer 0.5000000 0.5000000 Rheological Additive
Thermolabiles Tetrasodium glutamate diacetate 0.2000000 0.2000000 Chelator
10
Thermolabiles Pefume 0.5000000 0.5000000 Perfume
TOTAL 100,000000 100,000000
The same studies are applied to the two formulas presented in Example 2 in order to perform a comparative analysis. Studies are carried out both in silico, in vitro and in vivo following the legislation in force in the FPS study.
Table 2b - Results of the studies performed In silico, In vitro and In vivo with the compositions of Formula 2 regarding the degree of sun protection, and properties
of sensory composition
Method Without photodermic filters With photodermic filters Reference
In silico 35.7 35.7 A simulation of the in vivo sun protection factor (SPF, ISO24444) was performed. A description of the calculations made can be found in "In silico Determination of Topical Sun Protection", Bernd Herzog and Uli Osterwalder, Cosmetic Science Technology 2011, 62-70
In vitro 30 34 ISO 24444
In vivo 36.5 54.2 ISO 24443
Viscosity (1.1 - 1.9) PaS (1.1 - 1.9) PaS Reometer
Sensory Cream of easy extension and rapid absorption. Easy extension and quick absorption cream Visual inspection
The conclusions of the comparison made between the two variants of Formula 2 are as follows:
- The incorporation of the components called photodermic filters increases the SPF In vivo 1.5 times with respect to the formula without photodermic filters, maintaining the concentration of UV filters and therefore their SPF values In vitro and In silico.
- The addition of photodermic filters maintains the sensibility of the final product.
Example 3: Formula body sunscreen with theoretical SPF 50 with and without photodermic filters
A formula according to the present invention, called Formula 3, 5 is prepared in two variants: without part of the mayone of essential components listed in claim 1 (referred to as simplifying "photodermic filters") and with them, to prove the effects of its addition and the possible synergy with the rest of the components (photoprotective or UV filters, and excipients), with the concrete composition presented in Table 3 in percentages by weight with respect to the total of the composition:
Table 3a - Composition of Formula 2, with and without photodermic filters
Adding Phase Ingredients 0 /% (without filters) 0 /% (with filters) Category / function
Grease Cetyl potassium phosphate (and) hydrogenated palm glycerides 2,500,000 2,500000 Emulsifier
Grease Phenoxyethyl caprylate 6,000000 6,000000 Emollient
Grease Ethylhexyl Isononanoate 3,000000 3,000000 Emollient
Grease Tocopherol acetate - 0.500000 F. Photodermic
Grease Polyisobutene 2,500,000 2,5000000 Emollient
Grease Butyl methoxy dibenzoylmethane 4,500,000 4,500000 UV filter
Grease Octocrylene 10.000000 10.000000 UV filter
Grease Ethylhexyl salicylate 4,500000 4,500000 UV filter
Grease Diethylhexyl butamide triazone 3,500,000 3,500000 UV filter
Watery Water 49.594500 45.654500
Watery Allantoin - 1.000000 F. Photodermic
Watery Polyglyceryl-6 Stearate / Polyglyceryl-6 Behenate 1.000000 1.000000 Emulsifier
Watery Hydroxyacetophenone 0.500000 0.500000 Preservative
Watery Microcrystalline cellulose / Cellulose rubber 0.500000 0.500000 Rheological additive
Watery Xantana gum 0.400000 0.400000 Rheological additive
Watery Glycerin 3.000000 3.000000 Emollient
Watery Phenylbenzimidazole sulfonic acid 2,500,000 2,500000 UV filter
Watery Phenyl dibenzimidazole tetrasulfonate disodium 2.000000 2.000000 UV filter
Watery Sodium hydroxide 0.705500 0.705500 pH regulator
Thermolabiles Cyclopentasiloxane 2.000000 2.000000 Emollient
Thermolabiles 1,2-hexanediol and caprylic glycol 0.500000 0.500000 Preservative
Thermolabiles Panthenol - 2.000000 F. Photodermic
Thermolabiles Aloe barbadensis (leaf juice powder) - 0.100000 F. Photodermic
Thermolabiles Ascorbil sodium phosphate - 0.300000 F. photodermic
Thermolabiles Tocopherol - 0.040000 F. Photodermic
Thermolabiles Tetrasodium glutamate diacetate / Sodium hydroxide 0.2000000 0.2000000 Chelator
Thermolabiles Pefume 0.6000000 0.6000000 Perfume
TOTAL 100,000000 100,000000
The same studies are applied to the two formulas presented in Example 3 in order to perform a theoretical comparative analysis (measuring the SPF In vivo exclusively in the sample with photodermic filters).
5
Table 3b - Results of the studies carried out In silico, In vitro and In vivo with the compositions of Formula 1 regarding the degree of sun protection, and properties
of sensory composition
Method Without photodermic filters With photodermic filters Reference
In silico 49.6 49.6 A simulation of the sun protection factor was performed in vivo (SPF, ISO24444). A description of the calculations made can be found in "In silico Determination of Topical Sun Protection", Bernd Herzog and Uli Osterwalder, Cosmetic Science Technology 2011, 62-70
In vitro 52 51 ISO 24444
In vivo 50 (theoretical) 61.4 ISO 24443
Viscosity (0.6 - 1) PaS (0.6 - 1) PaS Reometer
Sensory Spray of easy extension and rapid absorption. Easy extension spray and rapid absorption Visual inspection
- The conclusions of the comparison made between the two variants of Formula 3 are as follows: In this example, an in vivo SPF 50+ (> 60) is achieved using UV filters equivalent to a SPF 50 plus the
5 combination of photodermic filters.
- The incorporation of the photodermic filters allows to start from a theoretical SPF (in public) 20% lower than the SPF required In vivo in this example (60).
- The addition of photodermic filters maintains the sensibility of the final product.
10
Example 4: Formula facial cream with theoretical SPF 2 with and without photodermic filters, compared with SPF 6 without photodermic filters.
A formula according to the present invention, called Formula 4, was prepared, as in the previous examples, in two variants: without part of the majority of 15 essential components listed in claim 1 (referred to as simplifying "photodermic filters") and with them, to verify the effects of their addition and of the possible synergy with the rest of the components (photoprotective or UV filters, and excipients), with the specific composition presented in Table 4 in percentages by weight with respect to the total of The composition In addition, a third composition of Formula 4 was prepared, without photodermic filters with SPF6:
Table 4a - Composition of Formula 4, with and without photodermic filters and without
photodermic filters with SPF6
Adding Phase Ingredients 0 /% (without filters) 0 /% (with filters) 0 /% (without filters, with SPF6) Category / function
Watery Disodium EDTA 0.100000 0.100000 0.100000 Chelator
Watery Water 75.820000 73.90000 71.870000
Watery Allantoin 0.500000 F. fotod.

Watery Jojoba hydrolyzed ester 0.400000 0.400000 0.400000 Emolient.
Watery Microcrystalline cellulose 0.200000 0.200000 0.200000 Rheological additive
Watery Xantana gum 0.400000 0.200000 0.150000 Rheological additive
Watery Glycerin 0.200000 4.000000 4.000000 Emolient.
Grease Phenoxyethyl caprylate 3,000,000 3,000,000 3,000,000 Emolient.
Grease Ethylhexyl palmitate 3,000000 3,000000 3.000000 Emolient.
Grease Olus oil 3,000000 3,000000 3.000000 Emolient.
Grease Octocrylene 0.500000 0.500000 3.000000 UV filter
Grease Ethylhexyl Salicylate - 1,500000 UV Filter
Grease Butyl methoxy dibenzoylmethane 0.250000 0.250000 1.000000 UV filter
Grease Cetearyl alcohol / Glyceryl stearate / PEG-40 stearate / Ceteareth-20 3.000000 3.000000 3.000000 Emulsio.
Grease Docosanol (behenyl alcohol) 2.000000 2.000000 1.250000 Rheology additive
Termolab Hydroxyacetophenone 0.600000 0.600000 0.600000 Conser.
Termolab Tocopherol acetate - 0.200000 F. fotoder.
Termolab Dimethicone / Dimethiconol 0.500000 0.500000 0.500000 Emolient.
Termolab Phenoxyethanol 0.400000 0.400000 0.400000 Conserv.
Termolab Soybean oil (soy glycine) 2.000000 2.000000 2.000000 Emolient.
Termolab Tocopherol - 0.020000 F. Fotoder.
Termolab Ascorbil sodium phosphate - 0.150000 F. fotoder.
Termolab Aloe barbadensis (leaf juice powder) - 0.050000 F. fotoder.
Termolab Panthenol 1.000000 F.
photoder
Termolab Pefume 0.250000 0.250000 0.250000 Perfume
Termolab Sodium hydroxide 0.030000 0.030000 0.030000 Regu. pH
Termolab Sodium polyacrylate / Hydrogenated polydicene / Trideceth-6 0.750000 0.750000 0.750000 Adit. reol.
TOTAL 100,000000 100,000000 100,000000
The same studies are applied to the three formulas presented in example 4 in order to perform a theoretical comparative analysis (measuring the SPF In vivo in the sample with photodermic filters and in SPF 6 without photodermic filters).
5
Table 4b - Results of the studies carried out In silico, In vitro and In vivo with the compositions of Formula 4 regarding the degree of sun protection, and properties
of sensory composition
Method Without photodermic filters With photodermic filters Without photodermic filters FPS 6 Reference
In silico 1.8 1.8 6 A simulation of the in vivo sun protection factor (SPF, ISO24444) was performed. A description of the calculations made can be found in "In silico Determination of Topical Sun Protection", Bernd Herzog and Uli Osterwalder, Cosmetic Science Technology 2011, 62-70
In vitro 2.9 3.0 5 ISO 24444
In vivo 2 (theoretical) 7.1 7.1 ISO 24443
Viscosity (3.5 - 4.5) PaS (2.5 - 3.5) PaS (4.1 - 5.1) PaS Reometer
Sensory Viscose cream Light cream Viscose cream Visual inspection
easy easy easy easy
extension and extension and extension and
rapi da rapi da rapi da
The conclusions of the comparison made between the two variants of Formula 2 are as follows:
- In this example, an FPS In vivo 7.1 (> 6) is achieved using filters
5 UV equivalent to an SPF 2 plus the combination of photodermic filters.
- The desired SPF can be achieved in this example (> 6), using 7.3 times less concentration of UV filters.
- The incorporation of the photodermic filters allows starting from a theoretical SPF (in public) 66% lower than the SPF required In vivo in this example (6).
10 - The addition of photodermic filters improves the sensoriality of the final product.
Example 5: Formula solar body milk with theoretical SPF 12, with and without photodermic filters
A formula was prepared in accordance with the present invention, called Formula 5, 15 in two variants: without part of the majority of essential components listed in claim 1 (referred to as simplifying "photodermic filters") and with them, to prove the effects of its addition and possible synergy with the other components (photoprotective or UV filters, and excipients), with the specific composition presented in Table 5 in percentages by weight with respect to the total of the composition:
Table 5a - Composition of Formula 5, with and without photodermic filters
Adding Phase Ingredients 0 /% (without filters) 0 /% (with filters) Category / function
Grease Cetyl phosphate potassium (and) hydrogenated palm glycerides 1,500,000 1,500,000 Emulsifier
Grease Glyceryl Stearate 0.300000 0.300000 Emollient
Grease Cetearil alcohol 1,500,000 1,500000 Rheological Additive.
Grease Phenoxyethyl caprylate 4.000000 4.000000 Emollient
Grease Ethylhexyl Isononanoate 3.000000 3.000000 Emollient
Grease Hydroxyacetophenone 0.500000 0.500000 Preservative
Grease Tocopherol acetate - 0.250000 F. Photodermic
Grease Butyl methoxy dibenzoylmethane 2.000000 2.000000 UV filter
Grease Octocrylene 5.000000 5.000000 UV filter
Grease Ethylhexyl salicylate 4,800,000 4,800000 UV filter
Watery Water 68.880000 66.910000
Watery Allantoin - 1.000000 F. Photodermic
Watery Carbomer 0.100000 0.100000 Rheological additive
Watery Xantana Gum 0.300000 0.300000 Rheological Additive
Watery Glycerin 5.000000 5.000000 Emollient
Watery Allantoin - 0.500000 F. Photodermic
Thermolabiles Cyclopentasiloxane 2.000000 2.000000 Emollient
Thermolabiles 1,2-hexanediol and caprilil glycol 0.300000 0.300000 Preservative
Thermolabiles Phenoxyethanol 0.200000 0.200000 Preservative
Thermolabiles Panthenol 1.000000 F. Photodermic
Thermolabiles Aloe barbadensis (leaf juice powder) - 0.050000 F. Photodermic
Thermolabiles Ascorbil sodium phosphate - 0.150000 F. Photodermic
Thermolabiles Tocopherol 0.020000 F. Photodermic
Thermolabiles Sodium hydroxide 0.019800 0.019800 pH regulator
Thermolabiles Tetrasodium glutamate diacetate 0.200000 0.200000 Chelator
Thermolabiles Pefume 0.4000000 0.4000000 Perfume
TOTAL 100,000000 100,000000
The same studies are applied to the two formulas presented in Example 5 in order to carry out a theoretical comparative study (measuring the SPF In vivo exclusively in the sample with photodermic filters).
5
Table 5b - Results of the studies performed In silico, In vitro and In vivo with the compositions of Formula 5 regarding the degree of sun protection, and properties
of sensory composition
Method Without photodermic filters With photodermic filters Reference
In silico 12.2 12.2 A simulation of the in vivo sun protection factor (SPF, ISO24444) was performed. A description of the calculations made can be found in "In silico Determination of Topical
Sun Protection ”, Bernd Herzog and Uli Osterwalder, Cosmetic Science Technology 2011, 62-70
In vitro 15 11 ISO 24444
In vivo 15 (theoretical) 32.2 ISO 24443
Viscosity (0.6 - 1) PaS (0.6 - 1) PaS Reometer
Sensory Milk of easy extension and rapid absorption. Milk of easy extension and rapid absorption Visual inspection
The conclusions of the comparison made between the two variants of Formula 3 are as follows:
5 - In this example, an FPS In vivo 32.2 (> 30) is achieved using
UV filters equivalent to an SPF 15 plus the combination of photodermic filters.
- The incorporation of photodermic filters allows starting from a theoretical SPF (In public) 59% lower than the SPF required In vivo in this example (30).
- The addition of photodermic filters maintains product sensory
10 final
Example 6: Formula solar body spray with theoretical SPF 6 with and without photodermic filters
A formula according to the present invention, called Formula 6, 15 was prepared in two variants: without part of the majority of essential components listed in claim 1 (referred to as simplifying "photodermic filters") and with them, to prove the effects of its addition and the possible synergy with the rest of the components (photoprotective or UV filters, and excipients), with the specific composition presented in Table 6 in percentages by weight with respect to the total of the composition:
Table 6a - Composition of Formula 6, with and without photodermic filters
Adding Phase Ingredients 0 /% (without filters) 0 /% (with filters) Category / function
Grease Cetyl phosphate potassium (and) hydrogenated palm glycerides 1,500,000 1,500,000 Emulsifier
Grease C12-C15 Alkyl benzoate 3.000000 3.000000 Emollient
Grease Ethylhexyl Isononanoate 3.000000 3.000000 Emollient
Grease Tocopherol acetate - 0.250000 F. Photodermic
Grease Polyisobutene 1,500,000 1,500,000 Emollient
Grease Butyl methoxy dibenzoylmethane 1.000000 1.000000 UV filter
Grease Octocrylene 3.000000 3.000000 UV filter
Grease Ethylhexyl salicylate 2.000000 2.000000 UV filter
Grease Hydroxyacetophenone 0.500000 0.500000 Preservative
Grease Polyglyceryl-6 Stearate / Polyglyceryl-6 Behenate 2,500,000 2,500,000 Emulsifier
Grease Microcrystalline cellulose 0.500000 0.500000 Rheological additive
Grease Xantana Gum 0.300000 0.300000 Rheological Additive
Watery Water 75.170000 73.200000
Watery Disodium EDTA 0.100000 0.100000 Chelator
Watery Glycerin 4.000000 4.000000 Emollient
Watery Allantoin - 0.500000 F. Photodermic
Thermolabiles Cyclopentasiloxane 2.000000 2.000000 Emollient
Thermolabiles 1,2-hexanediol and caprylic glycol 0.500000 0.500000 Preservative
Thermolabiles Panthenol - 1.000000 F. Photodermic
Thermolabiles Aloe barbadensis (leaf juice powder) - 0.050000 F. Photodermic
Thermolabiles Ascorbil sodium phosphate - 0.150000 F. Photodermic
Thermolabiles Tocopherol - 0.020000 F. Photodermic
Thermolabiles Sodium hydroxide 0.010500 0.010500 pH regulator
Thermolabiles Pefume 0.400000 0.400000 Perfume
TOTAL 100,000000 100,000000
The same studies are applied to the two formulas presented in Example 6 in order to perform a theoretical comparative analysis (measuring SPF In vivo exclusively in the sample with photodermic filters).
5
Table 6b - Results of the studies performed In silico, In vitro and In vivo with the compositions of Formula 6 regarding the degree of sun protection, and properties
of sensory composition
Method Without filters With filters Reference
photodermic photodermic
In silico 6.6 6.6 A simulation of the in vivo sun protection factor (SPF, ISO24444) was performed. A description of the calculations made can be found in "In silico Determination of Topical Sun Protection", Bernd Herzog and Uli Osterwalder, Cosmetic Science Technology 2011, 62-70
In vitro 7.5 8 ISO 24444
In vivo 7 (theoretical) 17.6 ISO 24443
Viscosity (0.2 - 0.3) PaS (0.2 - 0.3) PaS Reometer
Sensory Spray of easy extension and rapid absorption. Easy extension spray and rapid absorption Visual inspection
The conclusions of the comparison made between the two variants of Formula 6 are the following:
- In this example, an SPF In vivo 17.6 (> 15) is achieved using
5 UV filters equivalent to an SPF 7 plus the combination of photodermic filters.
- The incorporation of photodermic filters allows starting from a theoretical SPF (In silico) 56% lower than the SPF required In vivo in this example (15).
- The addition of photodermic filters maintains the sensibility of the final product.

权利要求:
Claims (14)
[1]
5
10
fifteen
twenty
25
30
35
1. A composition for sun protection and / or skin repair by exposure to sun radiation that is characterized by:
a) alantolna, in a concentration between 0.1 and 1%, including both limits;
b) panthenol, in a concentration between 0.1 and 5%, including both limits;
c) tocopherol acetate, in a concentration between 0.05 and 2%, including both limits;
d) tocopherol, in a concentration between 0.01 and 1%, including both limits;
e) sodium ascorbyl phosphate, in a concentration between 0.01 and 3%, including both limits, and
f) Aloe barbadensis, in a concentration between 0.001% and 5%, including both limits
as photodermic protectors, in percentage by weight with respect to the total weight of the composition.
[2]
2. The composition according to claim 1, further comprising at least one of the following photodermic protectors: licorice extract, in a percentage of up to 0.2% by weight of the total composition; ubiquinone, in a percentage of up to 0.2% by weight of the total composition; bisabolol, in a percentage of up to 0.2% by weight of the total composition; and raw material containing natural antioxidant compounds from the family of polyphenols and / or carotenoids, up to 0.5% by weight of the total composition.
[3]
3. The composition according to any one of claims 1 or 2, further comprising at least one photoprotective compound against solar radiation, being comprised in a concentration of between 0.1% and 30% by weight of the total weight of the composition.
[4]
4. The composition according to claim 3, wherein the at least one photoprotective compound is a protective compound against UVA and / or UVB ultraviolet radiation.
5
10
fifteen
twenty
25
30
35
[5]
5. The composition according to the preceding claim, wherein the at least one photoprotective compound is selected from the group consisting of:
- Bis-ethylhexyloxyphenol methoxyphenyl triazine, in a maximum of 10%
- Butyl methoxy dibenzoylmethane, in a maximum of 5%
- Diethylamino hydroxybenzoyl Hexyl Benzoate, in a maximum of 10%
- Phenyl dibenzimidazole tetrasulfonate disodium, in a maximum of 10%
- Drometrizol Trisiloxane, in a maximum of 15%
- (Nano) Methylene bis-benzotriazolyl tetramethylbutylphenol, in a maximum of 10%
- Terephthalidene-sulphonic dialcamphoric acid, in a maximum of 10%
- 4-Methylbenzylidene Camphor, in a maximum of 4%
- 3-benzophenone, in a maximum of 10%
- 4- benzophenone, in a maximum of 5%
- Diethylhexyl butamide triazone, in a maximum of 10%
- Ethylhexyl methoxycinnamate, in a maximum of 10%
- Ethylhexyl salicylate, in a maximum of 5%
- Ethylhexyl triazone, in a maximum of 5%
- Ethylhexyl dimethyl PABA, in a maximum of 10%
- Homomentil salicylate, in a maximum of 10%
- Isoamil p-methoxycinnamate, in a maximum of 10%
- Octocrileno, in a maximum of 10%
- Phenylbenzimidazole sulfonic acid, in a maximum of 8%
- Polysilicone 15, in a maximum of 10%
- Titanium dioxide, in a maximum of 25%
- (Nano) Bis-triphenyl triazine, in a maximum of 10% and any combination thereof.
[6]
6. The composition according to the preceding claim, wherein the photoprotective compound is present in the following percentage by weight with respect to the total weight of the composition:
- Butyl methoxy dibenzoylmethane: between 0.25% and 4.5%;
- Phenyl dibenzimidazole tetrasulfonate disodium: between 0.5% and 3%;
- Diethylhexyl butamide triazone: between 0.5% and 3%;
- Ethylhexyl salicylate: between 1.5% and 4.8%;
- Ethylhexyl triazone: between 2.5% and 4.5%
- Octocrylene: between 0.50% and 10%;
5
10
fifteen
twenty
25
30
35
- Phenylbenzimidazole sulfonic acid: between 1 and 3%; and any combination thereof.
[7]
7. A product characterized in that it comprises the composition described according to any one of the preceding claims, which is a cosmetic product for topical use for sun protection and repair of the skin.
[8]
8. A cosmetic product of topical use for the protection and solar repair of the skin, which includes:
a) allantoin, in a concentration between 0.1 and 1%;
b) panthenol, in a concentration between 0.1 and 5%;
c) tocopherol acetate, in a concentration between 0.05 and 2%;
d) tocopherol, in a concentration between 0.01 and 1%, including both limits;
e) sodium ascorbyl phosphate, in a concentration between 0.01 and 3%, and
f) Aloe barbadensis, in a concentration between 0.001% and 5% as photodermic protectors, in percentage by weight with respect to the total weight of the product, and including both limits.
[9]
9. The product according to any one of claims 7 or 8, which is selected from the group consisting of: cream, emulsion, lotion, gel, ointment and aerosol.
[10]
10. The product according to any one of claims 7 to 9, comprising:
- the set of photodermic protectors in a maximum concentration of 10% by weight of the total weight of the composition;
- at least one photoprotective compound in a concentration between
0.1% and 30%, both limits included; Y
- a sufficient amount of excipients.
[11]
11. The product according to the preceding claim, wherein the excipients are selected from the group consisting of: gelling agents, emulsifiers, surfactants, consistency factors, preservatives, emollients, humectants, rheology modifiers, pH adjusters, chelants, silicones, waxes, fragrances and perfumes, skin conditioners and any combination thereof.
[12]
12. The product according to any one of claims 7 to 11, which has a sun protection factor between 6 and 60.
5 13. A cosmetic use of the composition described in any one of the
claims 1 to 6, for sun protection of the skin and / or for skin repair by exposure to sun radiation.
[14]
14. A cosmetic use of the product described in any one of claims 7 10 to 12, for sun protection of the skin and / or for skin repair by exposure
to solar radiation.
[15]
15. The cosmetic use described in any one of claims 13 or 14, for the protection and / or repair of the facial or body skin by exposure to the radiation
15 solar.

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同族专利:

公开号 | 公开日

ES2631191B1|2018-06-06|

WO2017129838A1|2017-08-03|

引用文献:

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US20020192245A1|2001-04-17|2002-12-19|Jensen Claude Jarkae|Morinda Citrifolia enhanced protective night cream moisturizer|

CZ13908U1|2003-10-08|2004-01-05|Cpn Spol. S R.O.|Cosmetic preparation containing a high-molecular antioxidant component|

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CN102949300A|2011-08-31|2013-03-06|上海艾芮尔化妆品有限公司|Cosmetic taking vitamin B and amino acid as main raw materials|

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PCT/ES2016/070838| WO2017129838A1|2016-01-29|2016-11-24|Composition for solar protection and repairing of the skin by means of protective complexes|

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